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What is the meaning of bone fragility?

From the age of 30 onwards, decrease in bone tissue leads to inevitable bone mass loss. This is accentuated from the menopause onwards because of the lack of estrogen.

Bone mass evolves throughout life.

Bone mass evolution is divided in three phases:

1 – the rapid growth phase, from birth until the late 20s

2 – the more or less 10 year plateau phase: bone tissue is permanently renewed by a bone remodeling process. There is an equilibrium between bone destruction and formation, which contributes to maintaining bone mass.

3 – the physiological bone mass loss, once bone maturation is reached and continues until death: this phenomenon is different in men and in women.

    • Bone loss is slow, regular and linear in men : 0,5 to 1% per year.
    • In women, bone loss accelerates during menopause: 3 to 5% per year during two to three years, then 2% per year during the five to ten years following the menopause.

     It is referred to as rapid postmenopausal bone loss, which is due to a rise in bone destruction linked to an estrogen deficit. Bone mass reduction then stabilizes at around 0,5 to 1% per year.

    Osteoporosis may therefore occur when initial bone mass is to low or when bone loss is too rapid.


Once osteoporosis has been diagnosed (T-SCORE -2.5) women must take medical treatment. In cases where the T Score is -1, a vitamin D based food supplement is often recommended by doctors in order to preserve bone capital.

  • Vitamin D contributes to maintaining healthy bones.



 Sérélys Osteo is a 2 in 1 solution:

1 PureCyTonin® complexes help to reduce hot flushes, night sweats, insomnia etc.

2Vitamins K2 ** and D3 contribute to maintaining bone capital.

Sérélys Osteo therefore associates 2 vitamins: vitamin K2 and vitamin D3.

Vitamin D stimulates osteocalcin synthesis, whereas vitamin K2 is necessary to activate osteocalcin. Only osteocalcin activated by vitamin K2 mobilizes calcium on the bone.

Therefore, vitamin D and vitamin K2 work together so that the body uses calcium in an efficient way, promoting a healthy bone structure.

British Medical Journal, 2005 “…preventing fractures through calcium and vitamin D absorption is not sufficient…combining vitamin K, vitamin D and calcium seems more efficient…”

British Medical Journal , 2005 « … la prévention des fractures grâce à l’absorption de calcium et de vitamine D ne suffit pas… combiner la vitamine K, la vitamine D et le calcium semble plus efficace… »2

1 Unité 1018, Equipe : Hormones et Maladies Cardiovasculaires, Centre de recherche en Epidémiologie et Santé des Populations, Université Paris-Sud 11, Villejuif) – Octobre 2012

2 Thomas E Radecki, Calcium and vitamin D in preventing fractures. Vitamin K supplementation has powerful effect. British medical Journal. Juillet 2005.

  • Unit 1018, Team : Hormones and cardiovascular diseases, Research Center on Epidemiology and Population Health, Paris-Sud 11 University, Villejuif) – October 2012 2 Thomas E Radecki, Calcium and vitamin D in preventing fractures. Vitamin K supplementation has powerful effect. British Medical Journal. July 2005.


*Standardized and purified Cytoplasmic pollen extracts help to reduce menopausal disorders.

**menaquinone 7 contributes to maintaining normal bone structure.