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What are the perimenopause and menopause?

What is commonly known as the menopause can be divided into two phases: the perimenopause which is followed by the menopause.


What is the perimenopause ?

Perimenopause is the period of time before the Menopause. Its duration varies from one woman to another. The perimenopause lasts 3 to 5 years. It ends 12 months after the last period date, that is to say when the menopause starts. During Perimenopause, hormone levels fluctuate. Estrogens may increase which provokes swelling, breast pain and the levels then brutally diminish which leads to hot flushes and night sweats. This period may include weight gain. Progesterone disappearance is often followed by an absence of periods during several months or on the contrary very heavy periods. 2 years before for example.

What is the menopause?

The Menopause is a natural phenomenon which is characterized by a menstrual periods stop. It is considered that the menopause is confirmed after a 12-month period absence. The menopause normally occurs between 50 and 55 years of age, the average being 51. When the menopause occurs before the age of 41, it is called early menopause, after 55 it is named late menopause. Certain factors may modify menopause age. For example, smokers generally enter menopause two years earlier.


What are the discomforts?

Certain women do not perceive any discomforts during the menopause, however others suffer from severe discomforts which justify adapted care. Discomfort intensity and frequency vary from one woman to another : hot flushes, night sweats, sensitive joints, energy drop or low morale, weight gain, vaginal dryness…

What causes these discomforts?

During perimenopause hormones fluctuate and in accordance with their anarchic variation, they explain the numerous usual discomforts which occur during this period. At the start of the menopause, the ovaries completely stop producing female hormones, leading to an estrogen deficiency. Estrogens have an effect on numerous functions of the female body. Estrogen level decrease will therefore have a direct effect on the whole body.

Are you concerned?

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Existing solutions

Two types of solutions exist: Hormone therapy and food supplements.

Hormon Therapy


Synthetic solutions also known as Hormone Replacement Therapy (HRT) are intended for women suffering from discomforts caused by the menopause: hot flushes, night sweats, joint pains, vaginal dryness. HRT is usually undergone for 4 to 5 years. It consists in providing the body with synthetic hormones that the ovaries no longer produce, that is to say estrogen and progesterone.


Not every woman can undergo HRT, it is contraindicated in case of:

  • Breast Cancer
  • Progressive Endometrial Cancer
  • Lupus, meningioma or otospongiosis
  • Severe hepatic function disorder
  • Hypertension
  • Diabetes
  • Heart disease
  • Bleeding disorder
  • Venous or arterial thromboembolic events

Formal recommendations

Following a certain number of studies which have shown their limits, Hormone Replacement Therapy (HRT) is a subject of debate since the beginning of the year 2000.

  • HRT must not be prescribed or renewed systematically.
  • HRT is not recommended for women who have no symptoms.
  • HRT may be prescribed for troublesome menopausal discomforts, in particular hot flushes, which have an impact on quality of life.
  • The treated patient must be well informed and voluntary.
  • Only the lowest dose of HRT must be prescribed or renewed
  • Treatment duration must be limited to the duration of the troublesome discomforts
  • The benefit of continuing the treatment must be reassessed regularly, at least once a year
  • To prevent osteoporosis in women who have a high fracture risk, HRT can no longer be prescribed as a first choice but only if other indicated treatments in this case are poorly tolerated.

Natural food supplements

There are two sorts of natural food supplements: phytoestrogen based and non phytoestrogen based.

Phytoestrogen based solutions

Phytoestrogen based products bond with the same receptors as hormones. Despite their natural origin, they have a hormonal action which means there are many precautions to be taken, in particular for women who have had breast cancer or who have a family history of breast cancer. The following plants contain phytoestrogens: soya, red clover, Kudzu, licorice, hop, sage, Lucerne (alfalfa), flax, fennel (non-exhaustive list).

The Sérélys® Solutions

Sérélys® offers 2 PureCytonin® based natural food supplements (Patented complexes by Sérélys Pharma® laboratories, specific cytoplasmic extract and purified Pollen based):

  • Sérélys® Perimenopause/Menopause is generally suitable for menopausal women. It provides 320mg of PureCyTonin® complexes per day and 10mg of Vitamin E. PureCyTonin® helps to diminish discomforts linked to the menopause such as hot flushes, irritability, temporary fatigue, joint pains…
  • Sérélys® Osteo is suitable for menopausal women who wish to maintain healthy bones whilst relieving menopausal inconveniences. It is also suitable for women who have undergone HRT or taken steroids in the past, and who have therefore weakened their bone mass. Furthermore, it is also recommended to women who have a low calcium intake and who are consequently likely to have more fragile bones when reaching the menopause.

Sérélys® tablets are also recommended to women who have a cancer history and who are looking for a safe, efficient and natural solution to reduce the inconveniences caused by the menopause.